Skip to main content
. Author manuscript; available in PMC: 2019 Jan 1.
Published in final edited form as: Brain Struct Funct. 2017 Jul 27;223(1):195–210. doi: 10.1007/s00429-017-1482-3

Figure 6. Exercise-driven repair is associated with increased expression of plasticity-related proteins.

Figure 6

The binge-induced decrement in remaining granule neurons in the dentate gyrus of the female hippocampus is detectable immediately following binge (Binge 0) as well as 4 weeks later (Binge 28) (A). However, if animals exercise for at least 2 weeks post-binge, the number of granule neurons is normalized (B). Panel C depicts the total distance covered by animals that ran for 1, 2 or 3 weeks, beginning after 7 days of abstinence. One week of post-binge exercise increased the expression of pCREB, BDNF and IGF-1 (D). *p < 0.05 significantly different from control; **p < 0.05 significantly different from sedentary.