Table 3.
Results of bivariate analyses evaluating baseline correlates of predominant depression and anxiety trajectories over the 6-year study period
| Stable depressive trajectory | Increasing depressive trajectory | F or χ2, p | Stable anxiety trajectory | Increasing anxiety trajectory | F or χ2, p | |
|---|---|---|---|---|---|---|
|
| ||||||
| Mean (SE) or n (%) | Mean (SE) or n (%) | Mean (SE) or n (%) | ||||
| Age | 69.0 (0.34) | 71.8 (0.95) | 8.53, 0.004 | 69.5 (0.4) | 68.9 (0.8) | 0.47, 0.494 |
| Male sex | 160 (43.4%) | 32 (59.3%) | 4.80, 0.028 | 163 (46.4%) | 29 (40.3%) | 0.92, 0.339 |
| Education < 15 yrs | 116 (41.6%) | 19 (47.5%) | 0.50, 0.478 | 153 (57.3%) | 31 (59.6%) | 0.10, 0.440 |
| APOE ε4 carrier (total) | 102 (27.6%) | 13 (24.1%) | 0.30, 0.582 | 87 (24.8%) | 28 (38.9%) | 6.00, 0.014 |
| APOE ε4 male | 39 (24.4%) | 10 (31.3%) | 0.66, 0.272 | 34 (20.9%) | 15 (51.7%) | 12.34, 0.001 |
| APOE ε4 female | 63 (30.1%) | 3 (13.6%) | 2.66, 0.103 | 53 (28.2%) | 13 (20.2%) | 0.07, 0.789 |
| BDNFMet carrier (total) | 132 (38.5%) | 30 (55.6%) | 0.70, 0.405 | 125 (38.5%) | 31 (43.1%) | 0.52, 0.470 |
| BDNFMet male | 60 (40.3%) | 10 (31.3%) | 0.90, 0.342 | 56 (36.8%) | 14 (48.3%) | 1.34, 0.247 |
| BDNFMet female | 72 (37.1%) | 14 (63.6%) | 5.80, 0.016 | 69 (39.9%) | 17 (39.5%) | 0.00, 0.967 |
| Aβ+ (total) | 85 (23.0%) | 12 (22.2%) | 0.02, 0.894 | 80 (22.8%) | 17 (23.6%) | 0.02, 0.880 |
| Aβ+ male | 37 (23.1%) | 8 (25.0%) | 0.05, 0.819 | 39 (23.9%) | 6 (20.7%) | 0.14, 0.705 |
| Aβ+ female | 48 (23.0%) | 4 (18.2%) | 0.26, 0.609 | 41 (21.8%) | 11 (25.6%) | 0.29, 0.593 |
| Cortisol (total) | 144.1 (3.3) | 142.4 (8.3) | 0.04, 0.849 | 145.4 (3.4) | 136.2 (6.7) | 1.28, 0.258 |
| Cortisol male | 139.4 (5.1) | 139.8 (9.1) | 0.00, 0.974 | 141.2 (5.0) | 130.0 (9.9) | 0.78, 0.378 |
| Cortisol female | 147.6 (4.3) | 146.1 (15.8) | 0.10, 0.919 | 149.1 (4.7) | 140.3 (8.9) | 0.68, 0.411 |
| Executive function (total) | 0.05 (0.04) | −0.25 (0.09) | 6.40, 0.012 | 0.04 (0.04) | −0.14 (0.08) | 2.78, 0.096 |
| Executive function male | −0.07 (0.06) | −0.34 (0.13) | 3.48, 0.064 | −0.13 (0.06) | −0.06 (0.11) | 0.19, 0.664 |
| Executive function female | 0.14 (0.06) | −0.12 (0.14) | 1.92, 0.167 | 0.18 (0.06) | −0.18 (0.11) | 6.66, 0.011 |
| Attention (total) | 0.06 (0.04) | −0.27 (0.10) | 8.30, 0.004 | 0.05 (0.04) | −0.14 (0.08) | 3.28, 0.071 |
| Attention male | 0.12 (0.06) | −0.29 (0.14) | 7.56, 0.007 | 0.08 (0.06) | −0.04 (0.12) | 0.594, 0.442 |
| Attention female | 0.007 (0.5) | −0.24 (0.15) | 2.05, 0.153 | 0.02 (0.06) | −0.20 (0.10) | 2.77, 0.097 |
Note. Bolded F and p values indicate statistically significant differences between trajectory groups (p<0.05)