Table 4.
Adjusted odds ratios (ORs) and 95% confidence intervals (CIs) for 5 bins with increasing levels of GLM-generated risk scores
| Bins | Local and global regions | Local regions | Global regions | ||||||
|---|---|---|---|---|---|---|---|---|---|
|
| |||||||||
| P and N casesa | OR | 95% CI | P and N casesa | OR | 95% CI | P and N casesa | OR | 95% CI | |
| 1 | 29-84 | 1 | Baseline | 37-76 | 1 | Baseline | 47-66 | 1 | Baseline |
| 2 | 49-64 | 2.22 | [1.26, 3.89] | 53-60 | 1.81 | [1.06, 3.11] | 46-67 | 0.96 | [0.57, 0.64] |
| 3 | 52-61 | 2.47 | [1.41,4.33] | 50-63 | 1.63 | [0.95, 2.80] | 61-52 | 1.65 | [0.97, 2.79] |
| 4 | 69-44 | 4.54 | [2.58,8.01] | 68-45 | 3.10 | [1.80, 5.35] | 60-53 | 1.59 | [0.94, 2.69] |
| 5 | 84-30 | 8.11 | [4.49,14.68] | 75-39 | 3.95 | [2.28, 6.86] | 69-45 | 2.15 | [1.27, 3.66] |
| Pb | 0.0028 | 0.0117 | 0.0229 | ||||||
a
Number of P (cancer) and N (cancer-free) cases in the corresponding bin of cases.
b
P-value to analyse whether the slope of the regression trend line between the risk scores and the adjusted ORs is significantly different from zero.