Table 2.

Brief summary of activity-dependent transcriptional regulators implicated in neuropsychiatric disorders.

Disease or model		Targets	Findings	References
Alzheimer's disease	Human study	CREB, CBP/p300	Reduced CREB, pCREB (Ser133), and CBP/p300 levels in prefrontal cortex in Alzheimer's disease.	(Bartolotti et al., 2016)
		MEF2	Association of SNP rs190982 with Alzheimer's disease.	(Lambert et al., 2013) (Ruiz et al., 2014)
	Animal model	HDAC4, MeCP2	HDAC4 and MeCP2 are identified as top canonical pathways by proteomics analyses.	(Neuner et al., 2016)
		HDAC4	Increased nuclear HDAC4 levels in the hippocampus.	(Sen et al., 2015)
		CRTC1	Impaired learning-induced nuclear translocation of CRTC1.	(Parra-Damas et al., 2017; Parra-Damas et al., 2014)
			The changes in CRTC1/CREB target genes.
			Reduced memory in model mice was restored by hippocampal overexpression of CRTC1.
Autism/Rett syndrome	Human study	MECP2	Mutations in the MECP2 gene in approximately 90% of patients with Rett syndrome.	(Amir et al., 1999)
		MEF2	MEF2C haploinsufficiency in autism. Small deletion encompassing the MEF2C gene in autism.	(Novara et al., 2010)
				(Le Meur et al., 2010)
		HDAC4	HDAC4 haploinsufficiency in autism.	(Pinto et al., 2014)
	Animal model	MeCP2	Cognitive and social abnormalities.	(Ebert et al., 2013; Li et al., 2008; Moretti et al., 2006)
			Deficit in motor behavior.
		MEF2	Altered spine number and impaired memory.	(Barbosa et al., 2008)
Depression	Human study	CREB, HDAC4	Decreased levels of CREB and increased levels of HDAC4 in patients with depression.	(Hobara et al., 2010; Ren et al., 2011)
	Animal model	CREB, CRTC1, MEF2, MeCP2, HDAC4,	CREB overexpression in the dentate gyrus induces antidepressant-like behavior.	(Chen et al., 2001; Higuchi et al., 2016; Hutchinson et al., 2012; Lepack et al., 2016; Meylan et al., 2016a; Meylan et al., 2016b; Sailaja et al., 2012; Sarkar et al., 2014; Uchida et al., 2011)
			CRTC1 knockout mice showed increased depression-like behavior.
			Decreased Mef2 mRNA in depressed mice.
			Increased MeCP2-HDAC2 binding in depressed mice.
			MeCP2 mutant mice showed increased depression-like behavior.
			Hippocampal overexpression of HDAC4 induced depression-like behaviors.
			Increased HDAC4 in the hippocampus or medial prefrontal cortex of depressive mice.

Please note that the findings listed here do not cover all the contents of the reference papers and that we do not cite all the related articles here, due to the space limitation,