Table 3.
Threshold unit costs of the biomarker test variants allowed for equal cost-effectiveness compared to FIT.
| Sensitivity CRC (%)* | Specificity | ||||||
|---|---|---|---|---|---|---|---|
| 88 | 90 | 92 | 94 | 96 | 98 | 100 | |
| 60 | −1 | −1 | 1 | 3 | 6 | 8 | 11 |
| 70 | 6 | 9 | 9 | 12 | 14 | 17 | 19 |
| 80 | 15 | 17 | 19 | 21 | 23 | 25 | 27 |
| 90 | 25 | 27 | 29 | 32 | 34 | 35 | 36 |
| 100 | 38 | 40 | 42 | 44 | 46 | 48 | 50 |
CRC, colorectal cancer; FIT, fecal immunochemical test; Neg., calculated threshold cost was a negative value.
Although the average sensitivity for CRC is used to label the different biomarker test variants, the sensitivity for adenomas is varied accordingly (see Table 1).
The presented unit costs include costs for the test kit and the analysis of the test.