Table 3.
Loci with Suggestive Evidence Modifying the Effect of Thiazide on QRS and JT Intervals After Cross-Phenotype Meta-Analysis
| Locus | SNP | Chr | Positiona | CA | CAF | P | Univariate P-value
|
|
|---|---|---|---|---|---|---|---|---|
| QRS | JT | |||||||
| European Descent | ||||||||
| PIK3R6 | rs1295230 | 17 | 8682305 | T | 0.02 | 3×10−6 | 0.008 | 0.001 |
| African American | ||||||||
| ADGRB3 | rs6931354 | 6 | 69527128 | A | 0.21 | 1×10−7 | 0.005 | 0.0002 |
| ADCY8 | rs10108730 | 8 | 131767803 | T | 0.79 | 2×10−6 | 1×10−5 | 0.0003 |
| PREX1 | rs8119517 | 20 | 46464282 | A | 0.94 | 3×10−6 | 0.0005 | 0.02 |
| CDH13 | rs11649358 | 16 | 81415652 | A | 0.75 | 5×10−6 | 9×10−6 | 0.001 |
| Hispanic/Latino | ||||||||
| AK2 | rs11591185 | 1 | 33274771 | A | 0.07 | 2×10−6 | 7×10−7 | 3×10−5 |
| ASS1P14 | rs12578228 | 12 | 33030528 | T | 0.10 | 2×10−6 | 2×10−6 | 2×10−5 |
| GALNT13 | rs17553946 | 2 | 155055407 | A | 0.23 | 4×10−6 | 0.005 | 9×10−7 |
Abbreviations: CA, Coded allele; CAF, Coded allele frequency; Chr, Chromosome; JT, JT interval; P, P-value; QRS, QRS interval; SE, Standard error; SNP, Single nucleotide polymorphism
a
Build 36 Base-Pair Position