Table 4.

Gene-Sets with Enrichment for Genotype-Thiazide Interaction Effects

Trait	Population	Gene-Set	P	FDR
QT	Hispanic/Latino	Nucleotide Binding	5×10−6	0.004
		Metal Ion Binding	6×10−6	0.004
		tRNA Adenine-N1 Methyltransferase Activity	6×10−5	0.03
		Transcription Coactivator Activity	8×10−5	0.03
		Transcriptional Activity of SMAD2, SMAD3, SMAD4, Heterotrimer	0.0001	0.03
		Zinc Ion Binding	0.0002	0.04
		Other RNA Binding Protein	0.0002	0.04
		Insulin-like Growth Factor-2 mRNA Binding Proteins (IGF2BPS/IMPS/VICKZS)	0.0003	0.05
	Trans-Ethnic	General RNA Polymerase II Transcription	4×10−6	0.006
		Transcription	4×10−5	0.03
JT	African American	Transcription Factor TFIID Complex	7×10−5	0.05
		Aminoacyl-tRNA Synthetase Multienzyme Complex	0.0001	0.05
		tRNA Aminoacylation for Protein Translation	0.0001	0.05
		Transcription Factor TFTC Complex	0.0001	0.05
	Trans-Ethnic	Transciption	3×10−5	0.03
		General RNA Polymerase II Transcription Factor Activity	4×10−5	0.03

Abbreviations: FDR, False discovery rate; JT, JT interval; P, P-value; QT, QT interval