Fig. 5.

Excellent ICC between the OARSI grade evaluated from conventional histopathology and OARSI grade evaluated from CEμCT was observed (same three readers in both methods) (A.). Similarly, a fair ICC between the severity score (normal = 0, mild = 1, moderate = 2, severe = 3) evaluated from histology and μCT was demonstrated (same reader in both methods) (B.). The μCT score evaluated from μCT images by one reader and the μCT score evaluated form histology sections by a second blinded reader demonstrated an excellent ICC (C.). These results altogether (A.–C.) suggest that histopathological scoring from μCT images is possible and feasible. The number of overlapping data points has been indicated adjacent to such data points.