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. 2018 Jan 18;9:286. doi: 10.1038/s41467-017-02596-9

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© The Author(s) 2018

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 2 — Genetic association peaks at chromosomes a 7, b 8, and c 17. Genotypes include both “on array” SNPs and additional SNPs imputed as described in the Methods. The top associated “on array” SNP from the CCRLP/Kaiser discovery analysis is indicated by its “rs” identity (and purple diamond shape), and other SNPs are displayed by color showing their extent of genetic linkage with this top SNP. Recombination rate, genetic position, and the locations of nearby genes are indicated. The P values for the association at chromosome 7p15.3 (rs2390536, near SP4, OR = 1.20, 95% CI: 1.13–1.29, P = 3.6 × 10⁻⁸), chromosome 8q24.21 (rs4617118, OR = 1.27, 95% CI: 1.17–1.38, P = 3.1 × 10⁻⁹), and chromosome 17q12 (rs2290400, OR = 1.18, 95% CI: 1.11–1.25, P = 2.1 × 10⁻⁸)