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. 2018 Jan 18;9:286. doi: 10.1038/s41467-017-02596-9

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© The Author(s) 2018

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 3 — Chromatin contacts for the 8q24 top hit SNP. Chromosome contacts for lymphoblastoid cell line GM12878 are shown in the region surrounding the SNP. Two large domains to the left and right of the MYC gene are shown (analysis as described by Rao and Huntley¹⁹), alongside confirmed GWAS catalog alleles for any disease (diagonal line with green hatches indicating previously identified GWAS SNPs for any indication). Despite the large number of disease associations in this region, there are no known diseases with a GWAS hit at the same location as rs4617118. This SNP is located within the genome domain at the right side of the MYC locus. On the figure, distant chromatin contacts are indicated in red color off the diagonal, which is the co-occurrence of sequence using the Hi-C method. The annotations below the diagonal line indicate contact points (yellow lines), the top peaks of contact (cyan, or blue color), and chromatin loop calls (green)