Fig. 7.

FGF21KO and Klb AdipoKO mice have altered gene expressions in SAT. a The expression of the genes involved in adipogenesis and insulin signaling in SAT and VAT of WT and FGF21KO mice fed on HFD for 8 weeks. All the mice were killed during the fed state. n = 8–10. b Related gene expression in the SAT and VAT of WT and Klb AdipoKO mice fed with HFD for 8 weeks. All the mice were killed during the fed state. n = 8. c Related gene expression in SAT among WT + Vehicle, FGF21KO + Vehicle and FGF21KO + rmFGF21 groups after 4 weeks’ intervention. n = 6. These results were reproduced in four independent experiments. Data are presented as mean ± s.e.m. Significance was determined by student’s t test (a, b) and one-way ANOVA with Bonferroni multiple-comparison analysis (c). *P < 0.05