Table 2.
Cytogenotoxicity of BSH alone.
| Plating efficiency | Baseline CA frequency | |
|---|---|---|
| No BSH | 0.58 ± 0.02 | 0.027 ± 0.003 |
| 40 ppm 11B | 0.61 ± 0.04 | 0.027 ± 0.003 |
| 80 ppm 11B | 0.60 ± 0.04 | 0.023 ± 0.003 |
Plating efficiency (PE) values and total chromosome aberration (CA) yields in unirradiated DU145 prostate cancer cells (second column) and normal epithelial MCF-10A cells (third column), respectively, as a function of the amount of BSH. By definition, PE measures the survival of cells in the absence of radiation. Similarly, the recorded frequency of CAs in cells not exposed to radiation is referred to as baseline CA frequency. Data show lack of BSH-induced cyto- and genotoxicity at the used concentration.