Table 3.

Neuroanatomical correlates of emotion identification and reactivity in patient groups.

Group	Region	Side	Cluster	Peak (mm)			T score	PFWE
			(voxels)	x	y	z
Emotion identification
bvFTD	Anterior cingulate	L	196	−8	44	12	5.59	0.003
	Anterior insula	L	123	−30	27	0	4.07	0.047
	Supplementary motor area	L	5	−10	4	50	3.81	0.044
	Opercular IFG	L	32	−57	12	18	5.14	0.003
	Anteromedial temporal:
	Temporal pole	L	2133	−32	8	−38	5.11	0.010
	Amygdala			−24	2	−38	4.94	0.015
	Fusiform gyrus			−30	−9	−38	4.82	0.019
rtvFTD	Supplementary motor area	L	34	−3	−10	57	4.15	0.022
	Temporo-occipital junction	R	18	66	−50	−8	4.06	0.038
svPPA	STG/STS	L	536	−58	−30	14	7.21	0.005
	Supplementary motor area	L	19	−4	−2	50	4.23	0.019
	Opercular IFG	L	25	−57	12	18	5.05	0.003
	Anterior cingulate	L	24	−2	44	3	4.11	0.042
	Fusiform gyrus	R	44	22	−4	−44	4.43	0.042
nfvPPA	Supplementary motor area	L	37	−4	−2	50	4.14	0.023
	Opercular IFG	L	9	−52	8	18	3.96	0.033
Facial EMG reactivity
bvFTD	Supplementary motor area	L	12	−8	−9	56	3.99	0.030
	Temporo-occipital junction	L	25	−54	−45	−4	4.29	0.064
rtvFTD	Temporo-occipital junction	R	8	62	−62	2	3.96	0.046
svPPA	Parahippocampal gyrus	L	59	−20	−28	−24	4.25	0.028
	Parahippocampal gyrus	R	72	18	−33	−18	5.25	0.003
nfvPPA	Primary visual cortex	R	291	12	−80	3	5.92	0.001
	Primary motor cortex	R	521	56	8	27	5.43	0.007
	Supplementary motor area	R	18	8	8	68	4.42	0.012

The table presents regional grey matter correlates of mean overall emotion identification score and facial EMG reactivity (as defined in Fig. 1) during viewing of facial expressions in the four patient groups, based on voxel-based morphometry. Coordinates of local maxima are in standard MNI space. P values are all significant after family-wise error (FWE) correction for multiple voxel-wise comparisons within pre-specified anatomical regions of interest (see text). bvFTD, patient group with behavioural variant frontotemporal dementia (excluding right temporal cases); IFG, inferior frontal gyrus; nfvPPA, patient group with nonfluent variant primary progressive aphasia; rtvFTD, patient subgroup with right temporal variant frontotemporal dementia; STG/S, superior temporal gyrus/sulcus; svPPA, patient group with semantic variant primary progressive aphasia.