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. 2018 Jan 18;8:1161. doi: 10.1038/s41598-018-19516-6

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© The Author(s) 2018

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Activating effects of WJS on migration capacity of OVX-MSCs. (a) Wound assay of Sham-MSCs, OVX-MSCs-WJ(-), and OVX-MSCs-WJ(+). *P < 0.05. Data are expressed as mean ± SE of 4 BM-MSC cultures. The open wound area was measured at 6 h and 12 h after performing the cross-scratch. Yellow lines indicate the boundary of cell migration. (b) The ratio of open wound area at 6 h and 12 h compared with 0 h. Six cross-scratch points in each BM-MSC culture were measured. *P < 0.05. Data are expressed as mean ± SE of 4 BM-MSC cultures. (c) Chemotaxis assay of Sham-MSCs, OVX-MSCs-WJ(-), and OVX-MSCs-WJ(+). BM-MSCs induced to migrate to the opposite side of the membrane by SDF-1, IL-1β, and IL-6 as observed by confocal microscope. DAPI was used for counterstaining nuclei (blue). Bar: 100 μm. SDF-1, stromal cell-derived factor 1; IL-1β, interleukin-1 beta; IL-6, interleukin-6. (d) Numbers of BM-MSCs migrated to the opposite side of the membrane were counted in three fields of view for each BM-MSC type. *P < 0.05. Data are expressed as mean ± SE of 3 BM-MSC cultures.