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. 2018 Jan 18;8:1116. doi: 10.1038/s41598-017-18807-8

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© The Author(s) 2018

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Pancreatic beta-cell morphology and amyloid fibrils isolated from islets of hIAPP mice. (A) Pancreatic beta-cells of hIAPP mice were studied using transmission electron microscope. White bar depicts 200 nm, whereas black arrows represent insulin vesicles with aggregates. (B) Amyloid fibrils were isolated from pancreatic islets of hIAPP mice and fibrils were visualized using transmission electron microscope (white bar depicts 100 nm). wt/tg and tg/tg denote hemizygous or homozygous transgenic hIAPP mice, respectively. Representative areas are shown, n = 4–6 for A, n = 2–4 for B.