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. 2018 Jan 18;8:1116. doi: 10.1038/s41598-017-18807-8

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© The Author(s) 2018

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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The effect of EGCG on pancreatic islets of hIAPP mice. (A–C) Pancreata were stained with anti-insulin (green) and anti-amyloid fibril (91D7E8, red) antibodies and visualized by fluorescence microscopy. Cell nuclei were stained with DAPI (blue), white bars represent 50 µm. ins:insulin, amy:amyloid fibril, ov: overlay, NT:non-treated control group, EGCG:EGCG-treated group. Representative areas are shown. (D) The intensity of amyloid fibril staining was calculated using Architect software. (E) Pancreatic islet numbers were manually counted and numbers were normalized to total pancreas area. (F) Random-fed blood glucose levels. wt/tg and tg/tg denote hemizygous or homozygous transgenic hIAPP mice, respectively. Columns represent averages ± standard deviations; n = 4–7. ^#Denotes significant differences between wt/tg untreated and wt/tg EGCG-treated mice; ^#p < 0.05; *Denotes significant differences between wt/wt and tg/tg or wt/tg and tg/tg mice, respectively; **p < 0.01, ***p < 0.001.