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. 2018 Jan 18;8:1032. doi: 10.1038/s41598-018-19389-9

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© The Author(s) 2018

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Post-contrast, T1 weighted axial MRI images of all recurrences. (A–K) representative images prior to 1^st to 11^th surgical resections respectively. (L), representative image of final tumour progression. (A) age 6.79, underwent surgical resection of left frontal tumour. (B) age 7.33, left frontal craniotomy, partial resection, treated with radiotherapy and temozolomide. (C) age 9.11, left frontal subtotal resection, treated with CCNU and temozolomide. (D) age 11.26, biopsy. (E) age 13.10, resection. (F) age 14.04, resection. (G) age 14.29, right temporal craniotomy, gross total resection. (H) age 14.67, sphenoid tumour, endoscopic endonasal sphenoidectomy. (I) age 14.96, left temporal resection. (J) age 16.05, nasal biopsy. (K) age 16.17, nasal cavity resection. The patient died aged 16.42 years (Final).