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. 2018 Jan 18;8:1032. doi: 10.1038/s41598-018-19389-9

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© The Author(s) 2018

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Intratumoral heterogeneity and phylogentic reconstruction. (A) Contingency plots for cancer cell fractions (CCF) of somatic mutations identified in specimens (A–K). Key as provided in the figure. (B) Coxcomb plots for number of subclones in each specimen, with the area of each scaled according to the number of variants predicted to be contained within, as calculated by EXPANDS. They are placed along concentric circles according to the sampling time after initial diagnosis, and in distinct anatomical locations. (C) Phylogenetic tree of tumour specimens built using maximum parsimony from exome sequencing data. Blue line represents the ‘trunk’, yellow lines the shared major and minor ‘branches’, red lines the private ‘leaves’. Selected alterations are labelled, those targeting the NF-κB pathway are shaded.