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. 2018 Jan 18;8:1032. doi: 10.1038/s41598-018-19389-9

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© The Author(s) 2018

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

PMC Copyright notice

Integrated clinical and molecular inference of tumour evolution. Taking all available data, we proposed an evolutionary history along four distinct trajectories over 10 years. Brain diagram modified from Patrick J. Lynch, medical illustrator; C. Carl Jaffe, MD, cardiologist, under Creative Commons Attribution 2.5 License 2006. (https://upload.wikimedia.org/wikipedia/commons/4/44/Brain_human_lateral_view.svg).