Table 5.
Top 5 overrepresented transcription factor-binding sites from AHR:AHRR-co-bound, AHR-only and AHRR-only regions
| Overrepresentation analysis AHR:AHRR-co-bound regions | Overrepresentation analysis AHR-only | Overrepresentation analysis AHRR-only | |||||||
|---|---|---|---|---|---|---|---|---|---|
| Rank | TF Family | Description | Z score | TF family | Description | Z score | TF family | Description | Z score |
| 1 | AHRE | AHR–ARNT heterodimers | 42.1 | AP1 | Activating protein 1 | 17.2 | AHRE | AHR–ARNT heterodimers | 39.3 |
| 2 | AP2 | Activator protein 2 | 28.7 | AP2 | Activating protein 2 | 16.4 | NRF1 | Nuclear respiratory factor 1 | 18.2 |
| 3 | PAX9 | PAX-9 binding sites | 14. 6 | AP1R | MAF and AP1-related factors | 14.9 | ZF5F | ZF5 POZ domain zinc finger | 14.8 |
| 4 | AP1R | MAF and AP1-related factors | 12.5 | ERE | Estrogen response elements | 12.0 | EGRF | EGR/nerve growth factor-induced protein C | 14.0 |
| 5 | CTCF | CTCF and BORIS gene family | 12.1 | AHRE | AHR–ARNT heterodimers | 10.3 | E2F | E2F activator factor 1 | 13.8 |
AHR:AHRR-co-bound and AHR-only regions were probed against a genomic background, while AHRR-only were probed against a promoter background using Genomatix (http://www.genomatix.de/)