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. 2018 Jan 18;8:1097. doi: 10.1038/s41598-018-19619-0

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© The Author(s) 2018

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Natriuretic peptides activate mTOR-signalling in a cGMP-dependent manner in hMADS adipocytes. Representative blots (A) and quantitative bar graphs of mTOR Ser2448 phosphorylation relative to total mTOR (B), Raptor Ser792 phosphorylation relative to total Raptor (C), Rictor Thr1135 phosphorylation relative to total Rictor (D), in response to 20 min and 60 min treatment with BNP 100 nM in absence or presence of (Rp)-8-pCPT-cGMPS 100 µM (PKG inhibitor, PKGi). *p < 0.05, **p < 0.01, ***p < 0.0001 vs. control (n = 6).