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. 2018 Jan 18;8:1097. doi: 10.1038/s41598-018-19619-0

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© The Author(s) 2018

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Natriuretic peptides enhance glucose metabolism in human adipocytes. Effect of acute BNP 100 nM treatment on glucose oxidation (A), glucose incorporation into glycerol (B), and glucose incorporation into fatty acids (FA) (C) in hMADS adipocytes. (D) Effect of 100 nM BNP on glucose incorporation into FA in human isolated adipocytes. *p < 0.05 vs. control (n = 4–7). (E) Schematic model of NP-mediated glucose uptake in human adipocytes. Natriuretic peptides (NP) bind to a transmembrane receptor bearing a guanylyl cyclase activity called GC-A. Binding of NP to GC-A induces the production of cGMP and activation of cGK-I which activate Akt and mTORC2. Activation of mTORC2 phosphorylates Akt at Ser473 and enhances downstream signalling to the Rab-GTPase AS160 which promotes membrane GLUT4 translocation and glucose uptake. NP therefore promote glucose uptake and enhance glucose incorporation into glycerol and FA pools through de novo lipogenesis.