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. 2018 Jan 18;8:1118. doi: 10.1038/s41598-017-19063-6

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© The Author(s) 2018

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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IgG Ab and specificity responses in immunized mice. Groups of 6- to 8-week-old female C57BL/6 mice (n = 6) were immunized subcutaneously with 10 µg of each recombinant protein and Poly (I:C) (50 µg/dose) or Montanide ISA720 (7:3). IgG titres were measured by ELISA against the homologous proteins and individual full-length PvCSP variants. (a) PvCSP-VK210. (b) PvCSP-VK247, and (c) PvCSP-P. vivax-like. The results are expressed as the arithmetic mean titres of each group (log₁₀ ± SEM), and were compared by one-way ANOVA followed by Tukey test for multiple comparisons. Significant differences between groups are denoted on the graph as follows: *P < 0.05, **P < 0.01, and ***P < 0.001. Non-significant (ns) differences are indicated (P > 0.05). (d) The elicited Abs recognised the different allelic variants and were directed at the central repeats, as shown by assays against the repeats fused to flagellin FliC (FliC-PvCSP-repeats) after three doses.