Table 2.
Relative Predispositional Effect (RPE) analysis locus summary.
| Locus | RPE step | Peach allergy | Shrimp allergy | ||
|---|---|---|---|---|---|
| Significant alleles excluded | P-value | Significant alleles excluded | P-value | ||
| HLA-DRB1 | 0 | none | 4.27E-11 | none | 8.48E-15 |
| 1 | 09:01 | 9.25E-08 | 04:05 | 1.58E-02 | |
| 2 | 09:01, 14:05 | 2.16E-05 | 04:05, 15:01 | 1.35E-01 | |
| 3 | 09:01, 14:05, 15:01 | 0.0028 | |||
| 4 | 09:01, 14:05, 15:01, 15:02 | 0.1384 | |||
| HLA-DQB1 | 0 | none | 2.69E-12 | none | 3.37E-16 |
| 1 | 03:03 | 2.23E-08 | 04:01 | 1.12E-02 | |
| 2 | 03:03, 06:02 | 2.62E-06 | 04:01, 06:02 | 2.16E-01 | |
| 3 | 03:03, 06:02, 05:03 | 8.36E-04 | |||
| 4 | 03:03,06:02,05:03,06:01 | 0.2806 | |||
| HLA-DPB1 | 0 | none | 2.34E-03 | none | 5.16E-05 |
| 1 | 14:01 | 0.0357 | 06:01 | 7.69E-03 | |
| 2 | 14:01, 09:01 | 0.1787 | 06:01, 14:01 | 0.063 | |
P-value is for the 2xk chi-square test of significance of allergy status versus all HLA alleles at a locus after excluding alleles from both cases and control that were identified as “Significant alleles excluded” from the previous RPE step.