Table 3.
HLA-DRB1 | RPE step 0 | RPE step 1 | RPE step 2 | RPE step 3 | ||||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Allele frequency | P-value | OR | Allele frequency | P-value | OR | Allele frequency | P-value | OR | Allele frequency | P-value | OR | |||||
Controls | Cases | Controls | Cases | Controls | Cases | Controls | Cases | |||||||||
09:01 | 0.148 | 0.225 | 1.79E-07 | 1.67 | ||||||||||||
14:05 | 0.020 | 0.042 | 9.61E-05 | 2.21 | 0.023 | 0.055 | 9.98E-06 | 2.45 | ||||||||
15:01 | 0.077 | 0.111 | 2.16E-03 | 1.50 | 0.091 | 0.143 | 9.34E-05 | 1.68 | 0.093 | 0.152 | 2.69E-05 | 1.75 | ||||
15:02 | 0.107 | 0.134 | 0.033 | 1.29 | 0.125 | 0.173 | 2.22E-03 | 1.46 | 0.128 | 0.183 | 7.19E-04 | 1.52 | 0.141 | 0.216 | 4.82E-05 | 1.67 |
14:03 | 0.015 | 0.021 | 0.219 | 1.42 | 0.018 | 0.027 | 0.116 | 1.57 | 0.018 | 0.029 | 0.091 | 1.62 | 0.020 | 0.034 | 0.052 | 1.74 |
08:03 | 0.082 | 0.080 | 8.43E-01 | 0.97 | 0.097 | 0.103 | 0.627 | 1.08 | 0.099 | 0.109 | 0.468 | 1.12 | 0.109 | 0.129 | 0.222 | 1.21 |
04:05 | 0.131 | 0.077 | 9.19E-05 | 0.55 | 0.154 | 0.099 | 1.18E-03 | 0.61 | 0.157 | 0.105 | 2.67E-03 | 0.63 | 0.173 | 0.124 | 0.012 | 0.67 |
14:54 | 0.031 | 0.034 | 6.92E-01 | 1.09 | 0.037 | 0.044 | 4.05E-01 | 1.21 | 0.038 | 0.047 | 3.25E-01 | 1.25 | 0.042 | 0.055 | 0.195 | 1.34 |
12:02 | 0.020 | 0.008 | 0.043 | 0.41 | 0.023 | 0.011 | 0.073 | 0.45 | 0.024 | 0.011 | 0.087 | 0.47 | 0.026 | 0.013 | 0.120 | 0.50 |
01:01 | 0.060 | 0.034 | 8.61E-03 | 0.56 | 0.070 | 0.044 | 0.029 | 0.61 | 0.072 | 0.047 | 0.043 | 0.64 | 0.079 | 0.055 | 0.087 | 0.68 |
08:02 | 0.045 | 0.041 | 0.642 | 0.91 | 0.053 | 0.053 | 0.990 | 1.00 | 0.054 | 0.056 | 0.858 | 1.04 | 0.059 | 0.066 | 0.602 | 1.12 |
11:01 | 0.027 | 0.016 | 0.098 | 0.59 | 0.032 | 0.021 | 0.178 | 0.65 | 0.033 | 0.022 | 0.214 | 0.67 | 0.036 | 0.026 | 0.305 | 0.72 |
13:02 | 0.070 | 0.059 | 0.273 | 0.83 | 0.083 | 0.076 | 0.604 | 0.91 | 0.085 | 0.080 | 0.753 | 0.95 | 0.093 | 0.095 | 0.920 | 1.02 |
04:06 | 0.036 | 0.023 | 0.082 | 0.62 | 0.042 | 0.030 | 0.167 | 0.69 | 0.043 | 0.031 | 0.209 | 0.71 | 0.048 | 0.037 | 0.317 | 0.76 |
14:06 | 0.016 | 0.010 | 0.232 | 0.61 | 0.019 | 0.013 | 0.338 | 0.67 | 0.019 | 0.013 | 0.380 | 0.7 | 0.021 | 0.016 | 0.477 | 0.74 |
04:10 | 0.015 | 0.010 | 0.284 | 0.64 | 0.018 | 0.013 | 0.402 | 0.71 | 0.018 | 0.013 | 0.450 | 0.73 | 0.020 | 0.016 | 0.555 | 0.78 |
12:01 | 0.035 | 0.026 | 0.221 | 0.73 | 0.042 | 0.034 | 0.399 | 0.80 | 0.043 | 0.036 | 0.478 | 0.83 | 0.047 | 0.042 | 0.660 | 0.89 |
04:03 | 0.034 | 0.026 | 0.265 | 0.75 | 0.040 | 0.034 | 0.463 | 0.83 | 0.041 | 0.036 | 0.548 | 0.86 | 0.046 | 0.042 | 0.742 | 0.92 |
04:01 | 0.009 | 0.007 | 0.516 | 0.72 | 0.011 | 0.008 | 0.645 | 0.79 | ||||||||
16:02 | 0.008 | 0.010 | 0.703 | 1.17 | ||||||||||||
HLA-DQB1 | Controls | Cases | P-value | OR | Controls | Cases | P-value | OR | Controls | Cases | P-value | OR | Controls | Cases | P-value | OR |
03:03 | 0.160 | 0.238 | 1.41E-07 | 1.65 | ||||||||||||
06:02 | 0.072 | 0.104 | 2.05E-03 | 1.51 | 0.085 | 0.137 | 8.23E-05 | 1.70 | ||||||||
05:03 | 0.040 | 0.065 | 2.01E-03 | 1.66 | 0.048 | 0.085 | 1.77E-04 | 1.86 | 0.052 | 0.098 | 3.40E-05 | 1.99 | ||||
06:01 | 0.185 | 0.210 | 1.16E-01 | 1.17 | 0.220 | 0.275 | 4.11E-03 | 1.35 | 0.241 | 0.319 | 2.47E-04 | 1.48 | 0.254 | 0.354 | 1.28E-05 | 1.61 |
04:01 | 0.131 | 0.073 | 1.55E-05 | 0.52 | 0.156 | 0.095 | 2.71E-04 | 0.57 | 0.171 | 0.110 | 1.21E-03 | 0.60 | 0.180 | 0.122 | 4.03E-03 | 0.64 |
05:02 | 0.023 | 0.024 | 9.23E-01 | 1.03 | 0.027 | 0.031 | 0.635 | 1.14 | 0.030 | 0.036 | 0.484 | 1.21 | 0.032 | 0.040 | 0.371 | 1.27 |
05:01 | 0.063 | 0.033 | 1.99E-03 | 0.51 | 0.075 | 0.043 | 8.58E-03 | 0.56 | 0.082 | 0.050 | 1.85E-02 | 0.59 | 0.087 | 0.056 | 0.034 | 0.62 |
06:04 | 0.064 | 0.054 | 0.292 | 0.83 | 0.076 | 0.070 | 0.636 | 0.92 | 0.083 | 0.082 | 0.898 | 0.98 | 0.088 | 0.090 | 0.862 | 1.03 |
04:02 | 0.035 | 0.028 | 0.351 | 0.80 | 0.042 | 0.037 | 0.606 | 0.88 | 0.046 | 0.043 | 0.787 | 0.94 | 0.048 | 0.048 | 0.956 | 0.99 |
03:01 | 0.115 | 0.087 | 0.027 | 0.73 | 0.137 | 0.114 | 0.142 | 0.81 | 0.150 | 0.132 | 0.308 | 0.86 | 0.158 | 0.146 | 0.532 | 0.91 |
03:02 | 0.101 | 0.076 | 0.036 | 0.73 | 0.120 | 0.099 | 0.163 | 0.81 | 0.132 | 0.115 | 0.327 | 0.86 | 0.139 | 0.128 | 0.539 | 0.91 |
HLA-DPB1 | Controls | Cases | P-value | OR | Controls | Cases | P-value | OR | ||||||||
14:01 | 8.76E-03 | 0.021 | 2.27E-03 | 2.38 | ||||||||||||
09:01 | 0.095 | 0.125 | 0.014 | 1.35 | 0.096 | 0.128 | 0.010 | 1.37 | ||||||||
02:01 | 0.247 | 0.278 | 0.076 | 1.17 | 0.250 | 0.284 | 0.050 | 1.19 | ||||||||
04:02 | 0.100 | 0.074 | 0.037 | 0.73 | 0.100 | 0.076 | 0.045 | 0.74 | ||||||||
13:01 | 0.018 | 0.011 | 0.174 | 0.60 | 0.019 | 0.011 | 0.185 | 0.60 | ||||||||
02:02 | 0.028 | 0.021 | 0.262 | 0.73 | 0.028 | 0.021 | 0.281 | 0.74 | ||||||||
04:01 | 0.050 | 0.043 | 0.387 | 0.84 | 0.051 | 0.044 | 0.422 | 0.85 | ||||||||
14:01 | 8.76E-03 | 0.021 | 2.27E-03 | 2.38 | ||||||||||||
09:01 | 0.095 | 0.125 | 0.014 | 1.35 | 0.096 | 0.128 | 0.010 | 1.37 |