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. 2018 Jan 18;8:1022. doi: 10.1038/s41598-018-19314-0

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© The Author(s) 2018

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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LES and LEHet show reduced inhibitory transmission at the Purkinje cell-DCN cell synapse. (A) Recordings of eIPSCs in DCN neurons evoked by stimulating Purkinje axon with bipolar stimulator placed in the cerebellar white matter in LE, LEHet, and LES rats. Paired pulse stimulation with an interval of 50 ms. Note no identifiable current in LES DCN cells in response to Purkinje axon stimulation. (B) Summary of eIPSC amplitude in LE and LEHet DCN neurons. (C) No significant difference between the paired pulse ratio (PPR) in eIPSCs from LEHet and LE DCN neurons. (D) and (E) Whole cell voltage clamp recordings of eIPSCs in DCN neurons of LE (D) and LEHet (E) rats after stimulation at 20, 50, and 100 Hz. (F) Summary of failure rate in LE, LEHet, and LES DCN cells at 20 Hz, 50 Hz, and 100 Hz. LES cells showed 100% failure rate. *, **, and *** indicate p < 0.05, p < 0.01, and p < 0.001, respectively.