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. 2018 Jan 18;8:1058. doi: 10.1038/s41598-018-19548-y

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© The Author(s) 2018

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Activation of CD8⁺ T-cells by immunotherapies. (a) Mice were treated as described in the legend to Fig. 1. Mice (n = 5) were killed on day 14 and the IFNγ venus signal from CD8⁺ T-cells in the tumor, draining lymph node (dLN), non-draining lymph node (ndLN) and spleen was analyzed by flow cytometry. The number on each panel indicates the mean ± SD of the percentage of venus⁺ cells among CD8⁺ T-cells of 5 mice. (b) The absolute numbers of venus⁺ CD8⁺ T-cells and (c) mean fluorescent intensities (MFI) of venus signals of these cells were compared. Steel’s test was used for multiple comparisons between control and treatment groups (a). Dunnett’s test was used for multiple comparisons between control and treatment groups (b,c). **p < 0.01, ***p < 0.001.