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. 2018 Jan 18;8:1058. doi: 10.1038/s41598-018-19548-y

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© The Author(s) 2018

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Correlation between TRB CDR3 clonotype diversity in the tumor, T-cell effector function and anti-tumor activities. (a) Diversity Evenness 50 (DE₅₀) scores on the x-axis versus MFI values of IFNγ venus signal on the y-axis. Each dot indicates individual mice receiving no treatment (black circles), anti-PD-1(yellow), anti-CTLA-4 (grey), anti-4-1BB (blue), combination of anti-PD-1 and 4-1BB (purple) or anti-CD4 mAb (red). (b) Relationship between Diversity Evenness 50 (DE₅₀) scores, MFI values of IFNγ venus signal, the number of IFNγ⁺CD8⁺ cells in the tumor (cells/gram) and the tumor volume. The size of the circle indicates the tumor volume.