Figure 1.

Structural architecture of TRPV1 tetramer (a) in the side view and (b) in the top view. A representative subunit is colored by domain: the ARD (pink), the MPD linker (green), the S1-S2 linker (yellow), the S2-S3 linker (cyan), the S4-S5 linker (purple), the outer pore (including pore loop and pore helix, red), and the TRP helix (blue). Residues G643 and I679 at the upper and the lower gate are shown as spheres colored in light and dark gray, respectively. In (b), the heat-activated motions of the MPD linker, the S1-S2 linker, the S2-S3 linker, and the S4-S5 linker are marked by arrows colored by domain. To see this figure in color, go online.