Figure 10.

Damage contours d from $n=720$ axon model simulations with varying stretch λ and stretch rates $\dot{\lambda }$, without microtubule dynamics. Damage increases with increasing stretch and decreases with increasing stretch rate. Damage is initiated during loading, $\dot{\lambda }>0$(left), and continues to accumulate during holding, $\dot{\lambda }=0$ (right). As the cross-links remain stretched during holding, $\lambda >1$, the cross-link detachment rate is greater than the attachment rate, resulting in an overall increase in damage. To see this figure in color, go online.