Figure 7.

Cross-link model. All cross-links can dynamically detach from and reattach to their microtubules. The probability of cross-link detachment or reattachment $p=k/r_f\text{exp}\left(-F_0/r_f\left[k-k_0\right]\right)$ is a function of the detachment or reattachment rate $k=k_0\text{exp}\left(F/F_0\right)$ and the loading rate $r_f$. The detachment histograms illustrate the effects of varying the loading rate $r_f$ and the external force F in our discrete axon model in comparison to the solid lines of the analytical detachment probability p. To see this figure in color, go online.