Table 3.
Sensitivity and Specificity of MCM2, MCM5 and CDC6 Based on H- Score
| Markers | Sensitivity (%) | Specificity (%) | Positive predictive value (%) | Negative predictive value (%) |
|---|---|---|---|---|
| (95% CI) | (95% CI) | (95% CI) | (95% CI) | |
| MCM2 | 58.89 (48.02-69.16) | 73.68 (60.33-84.45) | 77.94 (66.24-87.09) | 53.16 (41.60-64.49) |
| MCM5 | 66.67 (55.94-76.25) | 70.18 (56.60-81.56) | 77.92 (67.02-86.58) | 57.14 (44.75-68.91) |
| CDC6 | 87.78 (79.18-93.73) | 70.18 (56.60-81.56) | 82.29 (73.17-89.33) | 78.43 (64.67-88.70) |
| MCM2 and MCM5 | 73.33 (62.97-82.10) | 59.65 (45.82-72.43) | 74.16 (63.79-82.86) | 58.62 (44.93-71.40) |
| MCM2 and CDC6 | 93.33 (86.04-97.50) | 59.65 (45.82-72.43) | 78.5 (69.51-85.86) | 85 (70.15-94.25) |
| MCM5 and CDC6 | 94.44 (87.5-98.15) | 50.88 (37.29-64.37) | 75.22 (66.22-82.86) | 85.29 (68.93-94.99) |
| MCM5, MCM2 and CDC6 | 94.44 (87.50-98.15) | 49.12 (35.63-62.71) | 74.56 (65.55-82.25) | 84.85 (68.09-94.83) |