Table 4.
Association of rs169969968 and rs3743074 with Lung Cancer; A, with Crude Odds Ratio ; B, with Odds Ratio Adjusted for Smoking
| A | ||||||||||||
| SNP ID | Variable | GENOTYPE MODEL | ||||||||||
| OR | 95% CI | SE | Z score | p Value | ||||||||
| rs16969968 | Het (GA) vs Common Hz (GG) | 1.66 | 0.98-2.81 | 0.4462 | 1.872 | 0.0612 | ||||||
| Rare Hz (AA) vs Common Hz (GG) | 4.99 | 1.97-12.64 | 2.36624 | 3.39 | 0.0007 | |||||||
| rs3743074 | Het (AG) vs Common Hz (AA) | 0.92 | 0.54-1.56 | 0.24781 | -0.313 | 0.7543 | ||||||
| Rare Hz (GG) vs Common Hz (AA) | 0.72 | 0.28-1.88 | 0.35331 | -0.661 | 0.5086 | |||||||
| Intercept | 0.38 | 0.24-0.61 | 0.09148 | -4.019 | <0.0001 | |||||||
| SNP ID | Variable | DOMINANT MODEL | ||||||||||
| OR | 95% CI | SE | Z score | p Value | ||||||||
| rs16969968 | Het + Rare Hz (GA+AA) vs GG | 2 | 1.21-3.28 | 0.50547 | 2.728 | 0.0064 | ||||||
| rs3743074 | Het + Rare Hz (AG+GG) vs AA | 0.79 | 0.48-1.30 | 0.19944 | -0.95 | 0.3421 | ||||||
| Intercept | 0.4 | 0.26-0.37 | 0.09441 | -3.879 | <0.0001 | |||||||
| SNP ID | Variable | RECESSIVE MODEL | ||||||||||
| OR | 95% CI | SE | Z score | p Value | ||||||||
| rs16969968 | Rare Hz (AA) vs (GA+GG) | 4.09 | 1.75-9.60 | 1.77136 | 3.256 | 0.0011 | ||||||
| rs3743074 | Rare Hz (GG) vs (AG+AA) | 0.61 | 0.25-1.46 | 0.27148 | -1.117 | 0.2640 | ||||||
| Intercept | 0.46 | 0.36-0.60 | 0.06088 | -5.862 | <0.0001 | |||||||
| B | ||||||||||||
| SNP ID | Variable | GENOTYPE MODEL | ||||||||||
| OR | 95% CI | SE | Z score | p Value | ||||||||
| Smoking | 2.4 | 1.45-3.98 | 0.61933 | 3.404 | 0.0007 | |||||||
| rs16969968 | Het (GA) vs Common Hz (GG) | 1.38 | 0.80-2.39 | 0.38566 | 1.167 | 0.2432 | ||||||
| Rare Hz (AA) vs Common Hz (GG) | 4.29 | 1.65-11.09 | 2.07795 | 3.003 | 0.0027 | |||||||
| rs3743074 | Het (AG) vs Common Hz (AA) | 0.88 | 0.51-1.51 | 0.2424 | -0.462 | 0.6441 | ||||||
| Rare Hz (GG) vs Common Hz (AA) | 0.68 | 0.26-1.80 | 0.33705 | -0.78 | 0.4354 | |||||||
| Intercept | 0.26 | 0.15-0.44 | 0.071 | -4.924 | <0.0001 | |||||||
| SNP ID | Variable | DOMINANT MODEL | ||||||||||
| OR | 95% CI | SE | Z score | p Value | ||||||||
| Smoking | 2.37 | 1.44-3.91 | 0.60464 | 3.396 | 0.0007 | |||||||
| rs16969968 | Het + Rare Hz (GA+AA) vs GG | 1.68 | 1.01-2.81 | 0.44027 | 1.984 | 0.0473 | ||||||
| rs3743074 | Het + Rare Hz (AG+GG) vs AA | 0.75 | 0.45-1.24 | 0.19414 | -1.115 | 0.2649 | ||||||
| Intercept | 0.27 | 0.16-0.46 | 0.0737 | -4.811 | <0.0001 | |||||||
| SNP ID | Variable | RECESSIVE MODEL | ||||||||||
| OR | 95% CI | SE | Z score | p Value | ||||||||
| Smoking | 2.54 | 1.55-4.16 | 0.64166 | 3.68 | 0.0002 | |||||||
| rs16969968 | Rare Hz (AA) vs (GA+GG) | 3.89 | 1.63-9.27 | 1.72306 | 3.065 | 0.0022 | ||||||
| rs3743074 | Rare Hz (GG) vs (AG+AA) | 0.63 | 0.26-1.53 | 0.286 | -1.023 | 0.3063 | ||||||
| Intercept | 0.27 | 0.18-0.41 | 0.0559 | -6.332 | <0.0001 | |||||||