Table 5.
Association of key SNPs in CHRNA3 and CHRNA5 with Lung Cancer in Different Populations
| Gene | SNP | Risk allele | MAF | Population | OR (p value) | Relation with lung cancer | Reference |
|---|---|---|---|---|---|---|---|
| CHRNA3 | rs1051730 | A>G | 0.36 | USA and UK | 1.8 (4.6 X 10-12) | association | Amos et al., (2008) |
| CHRNA3 | rs1051730 | A>G | 0.36 | European | 1.7 (1.1X10-7) | association | Thorgeirsson et al., (2008) |
| CHRNA5 | rs16969968 | G>A | 0.37 | European | 1.3 (1X10-20) | association | Hung et al., (2008) |
| CHRNA5 | rs16969968 | G>A | 0.04 | Chinese | 0.84 (0.347) | no association | Wu et al., (2009) |
| CHRNA5 | rs16969968 | G>A | 0.04 | African American | 1.27 (0.145) | association | Hansen et al., (2010) |
| CHRNA5 | rs17486278 | T>G | 0.29 | 1.28 (0.008) | association | ||
| CHRNA5 | rs16969968 | G>A | 0.001 | Japanese | 2.2 (0.00015) | association | Shiraishi et al., (2009) |
| CHRNA3 | rs1051730 | A>G | 0.014 | 2.4 (0.000088) | association | ||
| CHRNA5 | rs16969968 | G>A | 0.21 | Bangladeshi | 1.28 (not scored) | no association | Islam et al., (2013) |
| CHRNA5 | rs16969968 | G>A | 0.21 | Indian | 4.29 (0.0027) | association | Our study |
| CHRNA3 | rs3743074 | A>G | 0.33 | 0.68 (0.4354) | no association |