Table 4.
Cross- Reactivity of Anti-HER2 mAbs with Human HER Family Members and Cynomolgus Monkey HER2
mAbs | HER1 | HER2 | HER3 | HER4 | HER2 (Cynomolgus) |
---|---|---|---|---|---|
1F2 | - | + | - | - | + |
1T0 | - | + | - | - | + |
2A9 | - | + | - | - | + |
1H6 | - | + | - | - | + |
1H9 | - | + | - | - | + |
2A8 | - | + | - | - | + |
4C7 | - | + | - | - | + |
1B5 | - | + | - | - | + |
Trastuzumab | - | + | - | - | + |
Anti-His Ab | + | + | + | + | + |
The results represent OD values of <0.2 (-) and >2.0 (+)