Table 3.
Frequency of Recurrent Genetic Abnormalities Detected by Karyotyping, iFISH and MLPA (n=35)
| Abnormality | Gene | Karyotyping %(n) | iFISH %(n) | MLPA %(n) |
|---|---|---|---|---|
| Normal | - | 85.7%(n=30) | 42.9%(n=15) | 28.6%(n=10) |
| Abnormal | - | 14.3%(n=5) | 57.1%(n=20) | 71.4%(n=25) |
| t(4;14) | FGFR3, MMSET | - | 14.3%(n=5) | - |
| t(11;14) | CCND1 | - | 0%(n=0) | - |
| Amp (1q) | CKS1B, ANP32F, BCL-9, PDZK1 | - | - | 48.6%(n=17) |
| RB1, DIS3, DLEU1 | ||||
| Del (13q) | FAM46C, CDKN2C, FAF1 | - | 34.3%(n=12) | 34.3%(n=12) |
| Del (1p) | JAK2, COL5A1 | - | - | 34.3%(n=12) |
| Amp 9(p, q) | GABRB3 | - | - | 31.4%(n=11) |
| Amp (15q) | PCHAC | - | - | 28.6%(n=10) |
| Amp (5q) | C-MAF, CYLD, WWOX | - | - | 22.9%(n=8) |
| Del (16q) | CD27 | - | - | 20.0%(n=7) |
| Del (12p) | TRAF3 | - | - | 8.6%(n=3) |
| Del (14p) | TP53 | - | - | 8.6%(n=3) |
| Del (17p) | - | 8.6%(n=3) | 5.7%(n=2) |
Del, deletion;Amp, amplification;(-), not analysed.