Table 6.
Frequency of Recurrent Genetic Alterations Detected by iFISH and MLPA in Multiple Myeloma
| Genetic alteration | Alpar et al., 2013(13) | Boyle et al., 2015(25) | Zang et al., 2015(31) | In this study | ||||
|---|---|---|---|---|---|---|---|---|
| iFISH | MLPA | iFISH | MLPA | iFISH | MLPA | iFISH | MLPA | |
| t (4;14) | 15.00% | - | - | - | (IgH) | - | 14.30% | - |
| t (11;14) | 14.00% | 54.20% | 0% | |||||
| t (14;16) | 6.00% | - | ||||||
| t (8;14) | 0% | - | ||||||
| Del (1p) | 9.00% | 35.00% | 17.00% | 15.00% | - | 50.80% | - | 34.30% |
| Amp (1q) | 48.00% | 48.00% | 34.00% | 31.00% | 59.30% | 54.20% | - | 48.60% |
| Amp (5q) | 32.00% | 28.00% | - | - | - | 22.00% | - | 22.90% |
| Amp 9 (p, q) | - | - | - | - | - | - | - | 31.40% |
| Del (12p) | - | 20.00% | - | - | - | 20.30% | - | 11.40% |
| Del (13q) | 64.00% | 57.00% | 49.00% | 48.00% | 44.10% | 61.00% | 34.30% | 34.30% |
| Del (14p) | - | - | - | - | - | - | - | 8.60% |
| Amp (15q) | - | - | - | - | - | - | - | 28.60% |
| Del (16q) | - | 19.00% | 27.00% | 22.00% | - | 23.70% | - | 20.00% |
| Del (17p) | 7.00% | 9.00% | 7.00% | 4.60% | 14.10% | 11.90% | 8.60% | 5.70% |
Del, deletion;Amp, amplification;(-), not analysed