Table 5.
Association between Selected SNPs of SCNAs and Chronic OXAIPN (n=228)
| Gene and SNP | Total no. of patients, N=228 (%) | Grade 0 N=98 | Grade1 N=73 | Grade 2 N=55 | Grade 3 N=2 | Incidence of OXAIPN (Grade 1-3 Vs Grade 0) OR;(95%CI) | P value | Severity of OXAIPN (Grade 2+3 vs Grade 0+1) OR;(95%CI) | P value | |
|---|---|---|---|---|---|---|---|---|---|---|
| SCN4A–C?T rs2302237 | ||||||||||
| CC | 176 (77.2) | 74(75.5) | 60 (82.2) | 41 (74.5) | 1(50.0) | Reference | Reference | |||
| CT | 46 (20.2) | 21 (21.4) | 13 (17.8) | 11 (20.0) | 1 (50.0) | 1.15 (0.60-2.22) | 0.78 | 0.88 (0.42-1.86) | 0.9 | |
| TT | 6 (2.6) | 3 (3.1) | 0 (-) | 3 (5.5) | 0 (-) | 1.37 (0.27-7.02) | 0.69 | 0.31 (0.06-1.61) | 0.32 | |
| CC vs CT+TT | 1.18(0.63-2.2) | 0.71 | 0.77 (0.38-1.54) | 0.58 | ||||||
| CC +CT vs TT | 1.33 (0.26-6.77) | 0.72 | 0.32(0.06-1.64) | 0.33 | ||||||
| CT vs CC+TT | 0.8 (0.4-1.6) | 0.8 | 1.0 (0.5-2.2) | 0.8 | ||||||
| SCN5A-C ?G rs11720524 | ||||||||||
| CC | 165 (72.4) | 74 (75.5) | 46 (63.0) | 44 (80.0) | 1 (50.0) | Reference | Reference | |||
| CG | 52 (22.8) | 19 (19.4) | 21 (28.8) | 11 (20.0) | 1 (50.0) | 0.70 (0.37-1.34) | 0.37 | 1.25 (0.6-2.59) | 0.67 | |
| GG | 11 (4.8) | 5 (5.1) | 6 (8.2) | 0 (-) | 0 (-) | 1.02 (0.3-3.49) | 0.96 | - | - | |
| CC vs CG+GG | 0.75 (0.41-1.37) | 0.44 | 1.59 (0.77-3.26) | 0.26 | ||||||
| CC+CG vs GG | 1.11 (0.32-3.75) | 0.86 | - | - | ||||||
| CG vs CC+GG | 1.4 (0.7-2.6 ) | 0.3 | 0.87 (0.42-1.81) | 0.85 | ||||||
| SCN9A- G?A rs6746030 | ||||||||||
| GG | 160 (70.2) | 76 (77.6) | 47 (64.4) | 35 (63.7) | 2 (100.0) | Reference | Reference | |||
| AG | 61 (26.8) | 18 (18.4) | 23 (31.5) | 20 (36.3) | 0 (-) | 0.46 (0.24-0.87) | 0.02* | 0.61 (0.32-1.18) | 0.19 | |
| AA | 07 (3.0) | 4 (4.0) | 3 (4.1) | 0 (-) | 0 (-) | 1.4 (0.31-6.8) | 0.9 | - | - | |
| AG+AA vs GG | 1.8 (1.04-3.4S) | 0.04* | 0.72(0.38-1.36) | 0.4 | ||||||
| GG+AG vs AA | 1.8 (0.39-8.2) | 0.7 | - | - | ||||||
| AG vs GG+AA | 2.1 (1.17-4.1 ) | 0.1 | 1.7 (0.89-3.2 ) | 0.1 | ||||||
| SCN9A- T?G rs6754031 | ||||||||||
| TT | 109 (47.8) | 36 (36.7) | 37 (50.7) | 35 (63.7) | 1 (50.0) | Reference | Reference | |||
| TG | 89 (39.0) | 46 (46.9) | 30 (41.1) | 13 (23.6) | 0 (-) | 2.19 (1.21-3.86) | 0.01* | 2.88 (1.41-5.87) | 0.004* | |
| GG | 30 (13.2) | 16 (16.4) | 6 (8.2) | 7 (12.7) | 1 (50.0) | 2.31 (1.02-5.26) | 0.06* | 1.35 (0.55-3.34) | 0.65 | |
| TG+GG vs TT | 0.45 (0.22-0.77) | 0.005* | 0.43 (0.23-0.80) | 0.01* | ||||||
| TT+TG vs GG | 1.61 (0.74-3.4) | 0.3 | 0.9 (0.37-2.16) | 0.82 | ||||||
| TG vs TT+GG | 0.5 (0.32-0.9) | 0.04* | 0.36 (0.18-0.73) | 0.006* | ||||||
| SCN10- A?G rs12632942 | ||||||||||
| AA | 144 (63.2) | 65 (66.3) | 50 (68.5) | 27 (49.0) | 2 (100.0) | Reference | ||||
| AG | 78 (34.2) | 32 (32.6) | 23 (31.5) | 23 (41.8) | 0 (-) | 0.84 (0.48-1.47) | 0.65 | 0.6 (0.31-1.13) | 0.16 | |
| GG | 6 (2.6) | 1 (1.1) | 0 (-) | 5 (9.2) | 0 (-) | 0.24 (0.02-2.13) | 0.33 | 0.05 (0.005-0.44) | 0.001* | |
| AG+GG vs AA | 1.27 (0.73-2.19) | 0.47 | 1.9 (1.07-3.64) | 0.03* | ||||||
| AA+AG vs GG | 0.25 (0.02-2.24) | 0.36 | 0.06 (0.006-0.53) | 0.004* | ||||||
| AG vs AA+GG | 1.1 (0.64-1.9 ) | 0.7 | 1.42 (0.76 - 2.65) | 0.3 | ||||||
*
p value <0.05 is statistically significant;OR, Odd Ratio;95%CI, 95%Confidence Interval