Table 6.
Association between Selected SNPs of SCNAs and Chronic OXAIPN in Patients who Received a Median Dose ≥780 mg/m2 of Oxaliplatin (N=138)
| Gene and SNP | Total number of patients;N=138(%) | Grade0, N=45(%) | Grade1, N=47(%) | Grade2, N=45(%) | Grade3, N=1(%) | Incidence of OXAIPN;(Grade 1-3 vs Grade0 ) OR (95%CI) | P value | Incidence of OXAIPN;(Grade 2+3 vs Grade0+1 ) OR (95%CI) | P value |
|---|---|---|---|---|---|---|---|---|---|
| SCN4A–C?T rs2302237 | |||||||||
| CC | 114(82.6) | 39 (86.6) | 44 (93.6) | 31 (68.9) | 0 (0.0) | Reference | |||
| CT | 20 (14.5) | 5 (11.1) | 3 (6.4) | 11 (24.4) | 1 (100.0) | 0.6 (0.2-1.8) | 0.5 | 0.24 ( 0.09-066) | 0.008 |
| TT | 4 (2.9) | 1 (2.2) | 0 (0.0) | 3 (6.7) | 0 (0.0) | 0.6 (0.06-6.3) | 0.7 | 0.1 (0.01-1.2) | 0.1 |
| CT+TT vs CC | 1.56 (0.57-4.24) | 0.5 | 4.46 (1.77-11.24) | 0.002* | |||||
| CC+CT vs TT | 0.6 ( 0.06-6.7) | 0.7 | 0.1 ( 0.01-1.5) | 0.2 | |||||
| CT vs CC+TT | 1.53 (0.52-4.53) | 0.5 | 3.7 (1.39-9.8) | 0.01* | |||||
| SCN5A-C ?G rs11720524 | |||||||||
| CC | 95 (68.8) | 31 (68.8) | 30 (63.8) | 34 (75.6) | 0 (0.0) | Reference | |||
| CG | 38 (27.5) | 11 (24.5) | 15 (31.9) | 11 (24.4) | 1 (100.0) | 0.8 (0.3-1.9) | 0.8 | 1.2 (0.5-2.6) | 0.7 |
| GG | 5 (3.7) | 3 (6.7) | 2 (4.3) | 0 | 0 (0.0) | 3.0 ( 0.4-19.5) | 0.4 | - | - |
| CC vs CG+GG | 0.9 ( 0.4-2.1) | 0.9 | 1.4 ( 0.6-6.31) | 0.4 | |||||
| CC+CG vs GG | 3.2 (0.5-20.1) | 0.3 | - | - | |||||
| CG vs CC+GG | 1.26 ( 0.56-2.8) | 0.7 | 0.84 (0.40-1.99) | 0.9 | |||||
| SCN9A- G?A rs6746030 | |||||||||
| GG | 97 (70.3) | 30 (66.7 | 34 (72.3) | 32 (71.1) | 1 (100.0) | Reference | |||
| GA | 41 (29.7) | 15 (33.3) | 13 (27.7) | 13 (28.9) | 0 (0.0) | 1.2 (0.59-2.7) | 0.6 | 1.11 (0.5-2.4) | 0.9 |
| AA | Ab | - | - | - | - | - | - | - | - |
| GG vs AG+AA | - | - | - | - | |||||
| GG+AG vs AA | - | - | - | - | |||||
| GA vs GG+AA | 0.77 (0.36-1.67) | 0.6 | 0.9 (0.41-1.96) | 0.9 | |||||
| SCN9A- T?G rs6754031 | |||||||||
| TT | 61 (44.2) | 13 (28.9) | 18 (38.3) | 29 (64.4) | 1 (100.0) | Reference | |||
| TG | 56 (40.6) | 24 (53.3) | 23 (48.9) | 9 (20.0) | 0 (0.0) | 2.76 (1.23-6.22) | 0.02 | 5.05 (2.11-12.09) | 0.0003* |
| GG | 21 (15.2) | 8 (17.8) | 6 (12.8) | 7 (15.6) | 0 (0.0) | 2.2 (0.7-6.6) | 0.2 | 1.9 (0.6-5.4) | 0.3 |
| TG+GG vs TT | 0.38 (0.17-0.81) | 0.01 | 0.27 (0.12-0.57) | 0.0009* | |||||
| TT+TG vs GG | 1.33 ( 0.5-3.4) | 0.7 | 1.0 ( 0.3-2.6) | 1 | |||||
| TG vs TT+GG | 0.45 (0.22-0.94) | 0.05 | 0.23 ( 0.1-0.53) | 0.007* | |||||
| SCN10- A?G rs12632942 | |||||||||
| AA | 82 (59.4) | 31 (68.9) | 30 (63.8) | 20 (44.4) | 1 (100.0) | Reference | |||
| AG | 53 (38.4) | 14 (31.1) | 17 (36.2) | 22 (48.9) | 0 (0.0) | 0.5 ( 0.2-1.2) | 0.2 | 0.4 (0.20-1.07) | 0.08 |
| GG | 3 (2.2) | 0 | 0 | 3 (6.7) | 0 (0.0) | - | - | - | - |
| AG+GG vs AA | 1.82 (0.85-3.86) | 0.1 | 2.34 (1.13-3.39) | 0.03* | |||||
| AA+AG vs GG | - | - | - | - | |||||
| AG vs AA+GG | 1.59 (0.75-3.39) | 0.2 | 1.8 (0.87-3.71) | 0.15 |
*
p value <0.05 is statistically significant;OR, Odd Ratio;95%CI, 95%Confidence Interval