Fig. 11.

Effects of edaravone (MCI-186) on infarct volume 1 day after distal middle cerebral arterial occlusion. Expressed as the mean ± SE in 10 animals Comparison with the vehicle group: *p<0.05 (Dunnett’s test). (Reprinted from ref 39: ‘Effects of a novel free radical scavenger, MCI-186, on ischemic brain damage in the rat distal middle cerebral artery occlusion model’, J Pharmacol Exp Ther, Kawai H, Nakai H, Suga M, Yuki S, Watanabe T, Saito K, 1997, 281(2), pp. 921–927, reprinted by permission of The American Society for Pharmacology and Experimental Therapeutics, http://www.aspet.org)