Table 3.
Rate constants of reactions between edaravone and various radicals
| Radical | Reaction rate constant | Conditions | Reference |
|---|---|---|---|
| •OH | 3.0 × 1010 M−1s−1 | electron paramagnetic resonance (EPR) – spin trapping method with DMPO, 0.1 M phosphate buffer (pH 7.0) | 24 |
| 8.5 ± 0.4 × 109 M−1 s−1 | pulse radiolysis, H2O, (pH 7.0) | 25 | |
| Cl3COO• | 5.0 ± 0.2 × 108 M−1 s−1 | pulse radiolysis, iso-PrOH:H2O:CCl4 = 48:48:4 (% v/v), (pH 9.7) | 25 |
| N3• | 5.8 ± 0.3 × 109 M−1 s−1 | pulse radiolysis, H2O, (pH 9) | 25 |
| SO4•− | 6.0 ± 0.5 × 108 M−1 s−1 | pulse radiolysis, H2O, (pH 9) | 25 |
 |
6.28 × 101 M−1s−1(pH 6) | stopped-flow spectrophotometer, pH 6–8 (H2O/MeOH) | 26 |
| 1.08 × 102 M−1s−1(pH 8) | |||