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The cellular behaviors of ITCs. ITCs accumulate through simple diffusion and conjugation with GSH. The GSH-DTCs are excreted via membrane drug transporters. The GSH-DTCs also modify sulfhydryls or amines of cellular proteins by exchange reactions. The GSH-DTCs are exported through membrane drug transporters, such as multidrug resistance associated protein-1 (MRP1) and P-glycoprotein (Pgp).
