Fig. 6.

The structure of Nrf2 and Keap1. (A) Nrf2 has six Nrf2-ECH homology (Neh) domains. (B) Keap 1 consists of five domains, such as an N-terminal domain, a BTB (Broad complex/Tramtrack/Bric-a-brac) domain, a central linker domain [intervening region (IVR)], a Kelch repeat [double glycine-repeat (DGR)] domain and a C-terminal domain. Chemically reactive cysteines with SFN are illustrated in white font on a black ground. Functionally important cysteines are in black font on a white ground. (C) Nrf2 interacts with the Keap1 dimer at the DLG motif and the ETGE motif in the Neh2 domain to form the Keap1-Nrf2-Cul3 complex under basal conditions. Triangles represent electrophiles.