Table 2. Histological differences observed between intestinal failure-associated liver disease and non-alcoholic fatty liver disease.

Condition	Intestinal failure-associated liver disease	Non-alcoholic fatty liver disease
Cholestasis	Yes	No
Steatosis type	Macrovesicular and microvesicular	Mainly macrovesicular
Steatosis location	Periportal area	Pericentral area
Biliary tree changes	Obstruction: portal inflammation, oedema, ductal proliferation Ductopaenia	No obstruction No ductopaenia
Steatohepatitis	Rare	Common
Fibrosis	“Jigsaw” pattern: commences at portal end, then periportal followed by portal-portal bridging fibrosis then cirrhosis	Sinusoidal; ballooned hepatocytes with Mallory-Denk bodies; typically starts in pericentral area