Table 2.
Cases of serotonin syndrome reported, classified by opioid associated with report
| Drug | WHO database | Medline database | |
|---|---|---|---|
| Only suspected cause or among others | Only suspected cause | Number of published cases | |
| Opioid | |||
| Tramadol | 647 | 62 | 26 |
| Tapentadol | 115 | 42 | 1 |
| Fentanyl | 363 | 19 | 45 |
| Dextromethorphan | 86 | 7 | 12 |
| Pethidine | 66 | 6 | 5 |
| Hydromorphone | 41 | 3 | 2 |
| Buprenorphine | 20 | 3 | 1 |
| Oxycodone | 101 | 2 | 13 |
| Methadone | 93 | 2 | 3 |
| Morphine | 64 | 1 | 4 |
| Codeine | 32 | 0 | 0 |
| Hydrocodone | 6 | 0 | 2 |
| Dihydrocodeine | 4 | 0 | 0 |
| Oxymorphone | 3 | 0 | 0 |
| Serotonergic drugs for the treatment of depression | |||
| Fluoxetine | 641 | 181 | 54 |
| Citalopram | 777 | 178 | 57 |
| Duloxetine | 993 | 550 | 20 |
| Venlafaxine | 859 | 240 | 75 |