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Pretreatment with PRN473 impairs intravascular crawling. Intravascular crawling of neutrophils in the cremaster in WT and Btk −/− animals following PRN473 pretreatment as indicated. (A) Quantification of adherent cells that crawled presented as the mean percentage of cells that translocated throughout the observation period. (B) Average crawling distance. (C) Average crawling velocity. Data shown are means ± SEM, n = 5. # P < 0.05, significantly different as indicated.
