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. 2018 Jan 5;175(3):558–572. doi: 10.1111/bph.14109

Figure 1.

Figure 1

Graphs and photomicrographs illustrating the effect of intraplantar carrageenan (CA) injection on the temporal pattern of D‐serine and serine racemase (SeRa) expression in the spinal cord dorsal horn and on the PWF. (A) Ipsilateral D‐serine expression was significantly up‐regulated by day 3 post‐CA (F SDH = 15.36, F NP = 5.534, F NECK = 4.973). In contrast, contralateral D‐serine expression was increased between days 5 and 10 post‐CA injection (F SDH = 13.66, F NP = 4.739, F NECK = 2.803). (B) Similarly, the expression of ipsilateral SeRa was significantly up‐regulated by day 3 post‐CA injection (F = 4.894), while contralateral SeRa expression was significantly increased between days 5 and 10 post‐CA injection (F = 6.099). (C) CA injection induced a significant increase in ipsilateral PWF as early as 3 h post‐injection (F = 8.343). However, contralateral PWF showed a different developmental time course and was only significantly increased beginning on day 5 post‐CA injection (F = 7.526). *P < 0.05 as compared to that of sham animals. Scale bar = 150 μm.