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. 2018 Jan 5;175(3):558–572. doi: 10.1111/bph.14109

Figure 3.

Figure 3

Graphs illustrating the potential role of D‐serine on the PWF in carrageenan (CA)‐treated rats. Normal animals were injected i.t. with D‐serine (at doses of 1, 10 and 100 μg, single treatment). DAAO (0.01 and 0.1 U), LSOS (10 and 100 nmol) or vehicle (Veh) was administered i.t. twice a day on days 0–3 or from days 4–7 post‐CA injection. (A) I.t. injection of D‐serine (10 and 100 μg) dose‐dependently increased the PWFs to innocuous mechanical stimuli at 15 and 30 min and 1 and 2 h post‐injection (F 100ug = 4.607, F 10ug = 2.506). (B) Treatment with DAAO 0.1 U from days 0–3 post‐CA injection significantly blocked the increase in both ipsilateral (F = 6.349) and contralateral PWFs (F = 6.386). (C) Administration of LSOS 100 nmol on days 0–3 post‐CA injection also significantly inhibited the increase in ipsilateral (F = 5.000) and contralateral PWFs (F = 7.392). (D) Treatment with DAAO 0.1 U on days 4–7 post‐CA injection only blocked the increase in contralateral PWF (F = 2.798) but had no effect on the ipsilateral PWF. (E) Similarly, administration of LSOS 100 nmol on days 4–7 post‐CA injection also significantly blocked the increase in contralateral PWF (F = 3.722), whereas the ipsilateral PWF was not affected by LSOS treatment. *P < 0.05 as compared to that of vehicle‐treated normal rats (Veh). #P < 0.05 as compared to that of vehicle‐treated carrageenan rats (CA‐Veh).