Figure 2.

In vivo hypoglycaemic and insulinotropic activities of 33 in db/db mice as assessed by IPGTT. Saline, lixisenatide and 33 (25 nmol·kg⁻¹) were i.p. injected 30 min prior to 1 g·kg⁻¹ i.p. glucose load. (A) The time course of blood glucose levels in each group. (B) The calculated AUC_{glucose 0–120 min} values of each group. (C) The time course of plasma insulin levels in each group. (D) The calculated AUC_{insulin 0–120 min} values of each group. Results are presented as means ± SD, n = 6. ^* P < 0.05 versus control (saline), ^a P < 0.05 versus lixisenatide.