Figure 5.

Long‐term hypoglycaemic effects of lixisenatide and 33 tested by pre‐OGTT and multiple OGTT in db/db mice. Each group of mice were i.p. injected with saline (control), lixisenatide (25 nmol·kg⁻¹) or 33 (25 or 100 nmol·kg⁻¹) 120 min (A) or 360 min (B) prior to oral glucose loads (1.5 g·kg⁻¹). For multiple OGTT, mice were i.p. injected with saline (control), lixisenatide (25 nmol·kg⁻¹), or 33 (25 or 100 nmol·kg⁻¹) 0.5 h prior to the first glucose load (1.5 g·kg⁻¹), and glucose loads were repeated at 6 and 12 h. The blood glucose levels were detected at the times indicated. Results are presented as means ± SD, n = 6.